Svendsen P, Hau J, Chemnitz J, Teisner B
Placenta. 1984 Mar-Apr;5(2):175-82. doi: 10.1016/s0143-4004(84)80060-0.
Intravenous injection of small amounts of monospecific rabbit IgG against pregnancy-associated murine protein I (PAMP-I) induced abortion in mice where there was a histocompatibility difference between mother and fetuses. No abortion could be induced in inbred mice by a similar treatment. The maternal serum level was found to be higher in inbred than in outbred mice. The abortive dose of antibodies did not influence the serum levels of PAMP-I. Histological examination of uterine, placental and liver tissue showed only morphological changes in the placental tissue of mice which aborted due to the treatment with anti-PAMP-I antibodies.
静脉注射少量针对妊娠相关小鼠蛋白I（PAMP-I）的单特异性兔IgG，可在母胎存在组织相容性差异的小鼠中诱发流产。通过类似处理，近交系小鼠不会发生流产。研究发现，近交系小鼠的母体血清水平高于远交系小鼠。抗体的流产剂量不影响PAMP-I的血清水平。对子宫、胎盘和肝脏组织进行组织学检查发现，因抗PAMP-I抗体处理而流产的小鼠，其胎盘组织仅出现形态学变化。
