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妊娠相关小鼠蛋白-2与人妊娠特异性β1-糖蛋白的比较。

Comparison of the pregnancy-associated murine protein-2 and human pregnancy-specific beta 1-glycoprotein.

作者信息

Hau J, Westergaard J G, Svendsen P, Bach A, Teisner B

出版信息

J Reprod Fertil. 1980 Sep;60(1):115-9. doi: 10.1530/jrf.0.0600115.

DOI:10.1530/jrf.0.0600115
PMID:6968827
Abstract

Immunological cross-reaction between human pregnancy-specific beta 1-glycoprotein (SP-1) and pregnancy-associated murine protein-2 (alpha 2-PAMP, PAMP-2) was demonstrated by line immunoelectrophoresis using antibodies against the proteins raised in hens. The pattern of change of PAMP-2 and SP-1 values in serum during pregnancy was very similar. The murine placental growth-rate corresponded to PAMP-2 levels in maternal serum during pregnancy, indicating placental origin. We suggest that the mouse and its PAMP-2 can be used to study human SP-1.

摘要

通过使用针对在母鸡体内产生的这些蛋白质的抗体进行线免疫电泳,证明了人妊娠特异性β1-糖蛋白(SP-1)与妊娠相关鼠蛋白-2(α2-PAMP,PAMP-2)之间的免疫交叉反应。孕期血清中PAMP-2和SP-1值的变化模式非常相似。孕期小鼠胎盘生长速率与母体血清中PAMP-2水平相对应,表明其来源于胎盘。我们认为小鼠及其PAMP-2可用于研究人类SP-1。

相似文献

1
Comparison of the pregnancy-associated murine protein-2 and human pregnancy-specific beta 1-glycoprotein.妊娠相关小鼠蛋白-2与人妊娠特异性β1-糖蛋白的比较。
J Reprod Fertil. 1980 Sep;60(1):115-9. doi: 10.1530/jrf.0.0600115.
2
Comparison of pregnancy-associated murine protein-1 and human pregnancy zone protein.妊娠相关小鼠蛋白-1与人妊娠区带蛋白的比较。
J Reprod Immunol. 1981 Dec;3(6):341-9. doi: 10.1016/0165-0378(81)90050-4.
3
Immunochemical characterization and serum concentrations of pregnancy-associated serum proteins in mice.小鼠妊娠相关血清蛋白的免疫化学特性及血清浓度
J Reprod Fertil. 1980 Mar;58(2):389-93. doi: 10.1530/jrf.0.0580389.
4
The development of a murine model for the study of human pregnancy zone protein (PZP, alpha 2-PAG) and pregnancy-specific beta 1-glycoprotein (SP-1, PS beta G).用于研究人妊娠区蛋白(PZP,α2-PAG)和妊娠特异性β1-糖蛋白(SP-1,PSβG)的小鼠模型的建立。
Placenta Suppl. 1982;4:51-65.
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A comparison of assay methods for pregnancy specific beta 1 glycoprotein (SP-1).
Aust N Z J Obstet Gynaecol. 1980 May;20(2):109-12. doi: 10.1111/j.1479-828x.1980.tb00106.x.
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The new placental proteins (some observations on their clinical significance).
Ric Clin Lab. 1982 Jan-Mar;12(1):241-9.
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The ratio between molecular variants of pregnancy-specific beta 1 glycoprotein (SP1) in the peripheral and retroplacental circulation during later pregnancy.妊娠晚期外周血与胎盘后循环中妊娠特异性β1糖蛋白(SP1)分子变体之间的比例。
Placenta. 1980 Jul-Sep;1(3):223-6. doi: 10.1016/s0143-4004(80)80004-x.
8
[Pre-eclampsia and placental hormones (author's transl)].[子痫前期与胎盘激素(作者译)]
Geburtshilfe Frauenheilkd. 1980 Apr;40(4):339-43. doi: 10.1055/s-2008-1039318.
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Pregnancy-specific beta-glycoprotein (SP1) in normal pregnancy in Nigeria.尼日利亚正常妊娠中的妊娠特异性β-糖蛋白(SP1)
Int J Gynaecol Obstet. 1985 Sep;23(4):347-9. doi: 10.1016/0020-7292(85)90032-3.
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Pregnancy-specific beta 1-glycoprotein as a screening test for at-risk pregnancies.妊娠特异性β1-糖蛋白作为高危妊娠的筛查试验。
Am J Obstet Gynecol. 1981 Nov 1;141(5):499-502. doi: 10.1016/s0002-9378(15)33268-3.

引用本文的文献

1
Pregnancy-specific beta 1-glycoprotein: cDNA cloning, tissue expression, and species specificity of one member of the PS beta G family.
Hum Genet. 1989 Jun;82(3):239-43. doi: 10.1007/BF00291162.
2
A baboon model for pregnancy-associated antigens (PAPP-A, PP5, PP14).
Arch Gynecol Obstet. 1990;247(2):53-62. doi: 10.1007/BF02390662.