Hau J, Westergaard J G, Svendsen P, Bach A, Teisner B
J Reprod Fertil. 1980 Sep;60(1):115-9. doi: 10.1530/jrf.0.0600115.
Immunological cross-reaction between human pregnancy-specific beta 1-glycoprotein (SP-1) and pregnancy-associated murine protein-2 (alpha 2-PAMP, PAMP-2) was demonstrated by line immunoelectrophoresis using antibodies against the proteins raised in hens. The pattern of change of PAMP-2 and SP-1 values in serum during pregnancy was very similar. The murine placental growth-rate corresponded to PAMP-2 levels in maternal serum during pregnancy, indicating placental origin. We suggest that the mouse and its PAMP-2 can be used to study human SP-1.
通过使用针对在母鸡体内产生的这些蛋白质的抗体进行线免疫电泳,证明了人妊娠特异性β1-糖蛋白(SP-1)与妊娠相关鼠蛋白-2(α2-PAMP,PAMP-2)之间的免疫交叉反应。孕期血清中PAMP-2和SP-1值的变化模式非常相似。孕期小鼠胎盘生长速率与母体血清中PAMP-2水平相对应,表明其来源于胎盘。我们认为小鼠及其PAMP-2可用于研究人类SP-1。