Fox D P, Robertson F W, Brown T, Whitehead A R, Douglas J D
Undersea Biomed Res. 1984 Jun;11(2):193-204.
The incidence of chromosome gain and loss and chromosomal aberrations has been measured in 48-h lymphocyte cultures of divers and control subjects as part of an overall research program to identify possible long-term health hazards associated with commercial diving. When the two diving groups, air divers (n = 77) and helium-oxygen divers (n = 76), are compared with two control groups, oil rig workers (n = 75) and nonoil industry controls (n = 52), 3.9% (6 out of 153) had an unusually high number of structural aberrations in a small portion of the dividing lymphocytes. Similar damage was not found in controls. The remaining 147 divers had a similar low incidence of chromosomal aberrations to the two control groups. The factors responsible for this phenomenon are not known, but several aspects of diving can effectively be ruled out. These are: direct effects of pressure, breathing mixture, radiographic exposure, and viral infection. The causative agent must be acting locally on lymphocytes after their last maturation division. Further studies are continuing on this topic in an effort to identify the causative factor or factors.
作为一项旨在确定与商业潜水相关的可能长期健康危害的全面研究计划的一部分，已对潜水员和对照受试者的48小时淋巴细胞培养物中的染色体增减和染色体畸变发生率进行了测量。当将两个潜水组，即空气潜水员（n = 77）和氦氧潜水员（n = 76）与两个对照组，即石油钻井平台工人（n = 75）和非石油行业对照组（n = 52）进行比较时，3.9%（153人中的6人）在一小部分正在分裂的淋巴细胞中出现了异常高数量的结构畸变。在对照组中未发现类似损伤。其余147名潜水员的染色体畸变发生率与两个对照组相似。造成这种现象的因素尚不清楚，但潜水的几个方面可以有效排除。这些因素包括：压力的直接影响、呼吸混合气、射线照相暴露和病毒感染。致病因子必须在淋巴细胞最后一次成熟分裂后局部作用于它们。关于这个主题的进一步研究正在继续，以努力确定致病因素。
