四环素通过磷脂双分子层的扩散及其与磷脂的结合。
Tetracycline diffusion through phospholipid bilayers and binding to phospholipids.
作者信息
Argast M, Beck C F
出版信息
Antimicrob Agents Chemother. 1984 Aug;26(2):263-5. doi: 10.1128/AAC.26.2.263.
Abstract
The ability of tetracycline to pass through phospholipid bilayers by diffusion was investigated. Liposomes did not retain enclosed tetracycline. Accumulation of tetracycline was observed with liposomes containing entrapped Tet repressor protein. These results indicate that the drug can pass through lipid bilayers. The antibiotic was also shown to bind to liposomes and isolated phospholipids.
摘要
研究了四环素通过扩散穿过磷脂双层的能力。脂质体不能保留包裹的四环素。在含有截留的四环素阻遏蛋白的脂质体中观察到四环素的积累。这些结果表明该药物可以穿过脂质双层。还显示该抗生素与脂质体和分离的磷脂结合。
相似文献
1
Tetracycline diffusion through phospholipid bilayers and binding to phospholipids.四环素通过磷脂双分子层的扩散及其与磷脂的结合。
Antimicrob Agents Chemother. 1984 Aug;26(2):263-5. doi: 10.1128/AAC.26.2.263.
2
Structural characteristics of phospholipid multilamellar liposomes.磷脂多层脂质体的结构特征。
J Pharm Sci. 1984 Jan;73(1):122-5. doi: 10.1002/jps.2600730134.
3
Membrane insertion of cytochrome P450 1A2 promoted by anionic phospholipids.细胞色素P450 1A2的膜插入受阴离子磷脂促进。
Biochemistry. 1998 Sep 15;37(37):12860-6. doi: 10.1021/bi980804f.
4
Delta pH-dependent accumulation of tetracycline in Escherichia coli.大肠杆菌中四环素的ΔpH依赖性积累
Antimicrob Agents Chemother. 1991 Jan;35(1):53-6. doi: 10.1128/AAC.35.1.53.
5
[Chemiluminescence activation during lipid peroxidation by a europium--tetracycline complex].[铕 - 四环素络合物在脂质过氧化过程中的化学发光激活作用]
Biofizika. 1980 Sep-Oct;25(5):923-4.
6
Bilirubin-liposome interaction. Binding of bilirubin dianion, protonization, and aggregation of bilirubin acid.
J Biol Chem. 1981 May 10;256(9):4269-74.
7
Ion permeability of phospholipid bilayers.磷脂双分子层的离子通透性。
Nature. 1972 Oct 6;239(5371):342-4. doi: 10.1038/239342a0.
8
Incorporation of chemically modified proteins into liposomes.将化学修饰的蛋白质掺入脂质体中。
Acta Biol Med Ger. 1981;40(3):331-5.
9
Effects of calcium and neomycin on phase behavior of phospholipid bilayers.
J Pharm Sci. 1983 Dec;72(12):1465-7. doi: 10.1002/jps.2600721224.
10
Choline uptake by lipid liposomes and its diffusion across chloroform are saturable and inhibited by hemicholinium-3.
Gen Pharmacol. 1984;15(5):419-21. doi: 10.1016/0306-3623(84)90042-9.
引用本文的文献
1
Potential and Optimization of Mammalian Splice Riboswitches for the Regulation of Exon Skipping-Dependent Gene Expression and Isoform Switching within the Gene.用于调控基因内依赖外显子跳跃的基因表达和异构体转换的哺乳动物剪接核糖开关的潜力与优化
ACS Synth Biol. 2025 Mar 21;14(3):804-818. doi: 10.1021/acssynbio.4c00731. Epub 2025 Feb 26.
2
Influence of Environmental Conditions on the Escape Rates of Biocontained Genetically Engineered Microbes.环境条件对生物遏制的基因工程微生物逃逸率的影响
Environ Sci Technol. 2024 Dec 24;58(51):22657-22667. doi: 10.1021/acs.est.4c10893. Epub 2024 Dec 13.
3
An in vitro and ex vivo wound infection model to test topical and systemic treatment with antibiotics.一种用于测试局部和全身用抗生素治疗的体外和体内伤口感染模型。
J Appl Microbiol. 2022 Nov;133(5):2993-3006. doi: 10.1111/jam.15756. Epub 2022 Aug 9.
4
Efficient splicing-based RNA regulators for tetracycline-inducible gene expression in human cell culture and C. elegans.用于人类细胞培养和秀丽隐杆线虫中四环素诱导基因表达的基于高效剪接的RNA调节剂。
Nucleic Acids Res. 2021 Jul 9;49(12):e71. doi: 10.1093/nar/gkab233.
5
A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements.基于卷积神经网络的核酶基基因调控元件的预测和正向设计。
Elife. 2021 Apr 16;10:e59697. doi: 10.7554/eLife.59697.
6
Tetracycline regulated systems in functional oncogenomics.功能肿瘤基因组学中的四环素调控系统。
Transl Oncogenomics. 2007 Mar 28;2:17-33. Print 2007.
7
Inducible expression of transmembrane proteins on bacterial magnetic particles in Magnetospirillum magneticum AMB-1.诱导表达跨膜蛋白在趋磁细菌AMB-1 上的细菌磁性颗粒。
Appl Environ Microbiol. 2010 Feb;76(4):1152-7. doi: 10.1128/AEM.01755-09. Epub 2009 Dec 28.
8
Ultrasensitivity and noise propagation in a synthetic transcriptional cascade.合成转录级联反应中的超敏感性和噪声传播
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3581-6. doi: 10.1073/pnas.0408507102. Epub 2005 Feb 28.
9
Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.具有多个质子化位点的亲脂性药物进入细菌细胞的机制：以四环素和氟喹诺酮类药物为例
Antimicrob Agents Chemother. 1993 Jul;37(7):1393-9. doi: 10.1128/AAC.37.7.1393.
10
Tetracycline uptake by susceptible Escherichia coli cells.
Arch Microbiol. 1985 Apr;141(3):260-5. doi: 10.1007/BF00408069.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Active uptake of tetracycline by membrane vesicles from susceptible Escherichia coli.敏感型大肠杆菌的膜囊泡对四环素的主动摄取。
Antimicrob Agents Chemother. 1981 Sep;20(3):307-13. doi: 10.1128/AAC.20.3.307.
3
Control of expression of the Tn10-encoded tetracycline resistance genes. Equilibrium and kinetic investigation of the regulatory reactions.Tn10编码的四环素抗性基因表达的调控。调控反应的平衡和动力学研究。
J Mol Biol. 1983 Sep 25;169(3):707-21. doi: 10.1016/s0022-2836(83)80166-1.
4
Transport of antibiotics into bacteria.
Adv Microb Physiol. 1982;23:183-240. doi: 10.1016/s0065-2911(08)60338-0.
5
Uptake of tetracycline by Escherichia coli: lack of binding of tetracycline to the uptake system.
Biochem Biophys Res Commun. 1972 Sep 5;48(5):1129-32. doi: 10.1016/0006-291x(72)90827-3.
6
New aspects of liposomes.脂质体的新方面。
Biochim Biophys Acta. 1976 Dec 14;457(3-4):259-302. doi: 10.1016/0304-4157(76)90002-2.
7
Two transport systems for tetracycline in sensitive Escherichia coli: critical role for an initial rapid uptake system insensitive to energy inhibitors.敏感型大肠杆菌中四环素的两种转运系统：对能量抑制剂不敏感的初始快速摄取系统的关键作用。
Antimicrob Agents Chemother. 1978 Aug;14(2):201-9. doi: 10.1128/AAC.14.2.201.
8
Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.通过反相蒸发制备具有大内部水相空间和高包封率脂质体的方法。
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4194-8. doi: 10.1073/pnas.75.9.4194.
Zotero 插件