Praznikov V P
Biull Eksp Biol Med. 1984 Sep;98(9):264-6.
In 12-day-old rats, L-DOPA, a precursor of catecholamine synthesis, provokes an increase in the rate of the motor reactions (MR) of the shudder type. Reserpine which promotes catecholamine release from the tissues, leads to the diminution of the rate of the MR of the shudder type in rats of the same age. Aminazine, an alpha-adrenoblocker and antagonist of dopamine receptors, decreases the rate of the MR of the shudder type. Administration of aminazine in a dose of 10 mg/kg at different age periods produces inconclusive changes in the diminution of the rate of the MR of the shudder type. During sudden changes in the growth, the rate of the above-described modulations substantially decreases. The high rate of the MR of the shudder type seen in rats in the early postnatal period is a consequence of the marked activity of the catecholaminergic (dopaminergic) systems during that period. Reduction in the effect of the decreased MR rate produced by the same dose of aminazine during the critical periods of the growth also attests to the high activity of the catecholaminergic (dopaminergic) system in rats at that period.
在12日龄大鼠中，儿茶酚胺合成的前体左旋多巴会引发颤搐型运动反应（MR）速率的增加。促进儿茶酚胺从组织中释放的利血平会导致同年龄大鼠颤搐型MR速率降低。α-肾上腺素阻滞剂及多巴胺受体拮抗剂氯丙嗪会降低颤搐型MR的速率。在不同年龄阶段给予10毫克/千克剂量的氯丙嗪，对颤搐型MR速率降低的影响并不确定。在生长突然变化期间，上述调节的速率会大幅下降。出生后早期大鼠中所见的高颤搐型MR速率是该时期儿茶酚胺能（多巴胺能）系统显著活性的结果。在生长的关键时期，相同剂量氯丙嗪所产生的MR速率降低效应的减弱也证明了该时期大鼠儿茶酚胺能（多巴胺能）系统的高活性。
