Zakusov V V, Kozhechkin S N
Biull Eksp Biol Med. 1984 Sep;98(9):303-5.
Spontaneous electric activity of single neurons of the sensorimotor cortex was recorded extracellularly in experiments on unanesthetized rabbits. During microiontophoretic application of tropane and acetylcholine to the neurons, the response to both the agents was the same. The cells excitable by acetylcholine are also excitable by tropane, while those inhibited by acetylcholine are also inhibited by tropane. The cells that do not respond to acetylcholine are also irresponsive to tropane. The excitatory response pattern to tropane is similar to that of acetylcholine. Under the same conditions of microiontophoretic application, tropane causes less excitation as compared with acetylcholine. Tropane preliminarily applied to the neuron reduces the excitatory effect of acetylcholine. The possible role of agonist-antagonist relations between tropane and acetylcholine in the mechanism of the pharmacological effects of tropane and its derivatives is discussed.
在对未麻醉兔子进行的实验中，细胞外记录了感觉运动皮层单个神经元的自发电活动。在对神经元进行微离子电泳施加托烷和乙酰胆碱的过程中，两种药物的反应相同。对乙酰胆碱可兴奋的细胞对托烷也可兴奋，而对乙酰胆碱抑制的细胞对托烷也抑制。对乙酰胆碱无反应的细胞对托烷也无反应。托烷的兴奋反应模式与乙酰胆碱相似。在相同的微离子电泳施加条件下，与乙酰胆碱相比，托烷引起的兴奋较小。预先施加于神经元的托烷会降低乙酰胆碱的兴奋作用。讨论了托烷和乙酰胆碱之间激动剂 - 拮抗剂关系在托烷及其衍生物药理作用机制中的可能作用。
