Zakusov V V, Kozhechkin S N, Kostochka L M
Farmakol Toksikol. 1981 Sep-Oct;44(5):529-31.
The effect of tropan on exocellular-recorded electrical activity of brain sensorimotor cortical and ventrolateral thalamic neurons was studied in acute experiments on rabbits. Tropan was injected intravenously in a dose of 1-5 mg/kg and applied microiontophoretically to individual neurons. With both routes of administration tropan increased the frequency of spontaneous activity of the majority of cortical and thalamic neurons in the dose-dependent form. The inhibitory action of the microiontophoretically applied catecholamines noradrenaline and dopamine on the activity of brain cortical neurons does not change under the effect of tropan. The stimulatory effect of catecholamines on ventrolateral thalamic neurons is potentiated by tropan. It is suggested that excitation of cortical and subcortical neurons, as well as potentiation of stimulatory catecholaminergic effects in the subcortex underlie the central stimulant effect of tropan.
在对家兔进行的急性实验中，研究了托烷对大脑感觉运动皮层和丘脑腹外侧神经元细胞外记录的电活动的影响。托烷以1-5mg/kg的剂量静脉注射，并通过微离子透入法作用于单个神经元。通过这两种给药途径，托烷均以剂量依赖性形式增加了大多数皮层和丘脑神经元的自发活动频率。微离子透入法应用的儿茶酚胺去甲肾上腺素和多巴胺对大脑皮层神经元活动的抑制作用在托烷的作用下没有改变。托烷增强了儿茶酚胺对丘脑腹外侧神经元的刺激作用。提示皮层和皮层下神经元的兴奋以及皮层下刺激儿茶酚胺能效应的增强是托烷中枢兴奋作用的基础。
