Hiller C, Bischoff M, Schmidt A, Bender K
Hum Genet. 1978 Apr 24;41(3):301-12. doi: 10.1007/BF00284764.
1242 HLA-ABC haplotypes of the North German population (Hambrug) as deduced by family analyses are described. They are in perfect agreement with recently published data by Mayr (1977) from Austria (Vienna) in all parameters tested: frequency of the single HLA-alleles, haplotype distribution and linkage disequilibrium values. Gametic association studies revealed that 69.4% of the B and C genes (map distance 0.2cM) 36.9% of the A and C genes (0.6 cM), but only 23.2% of the A and B genes (0.8 cM) were significantly more often combined than expected due to their frequencies. From these findings it seems likely that the linkage disequilibrium within the MHC is rather due to a short evolutionary period than to selective forces. Some observations as to the most common European haplotype A1,B8 are discussed.
本文描述了通过家系分析推导得出的1242种德国北部人群（汉堡）的HLA - ABC单倍型。在所有测试参数方面，它们与迈尔（1977年）近期发表的来自奥地利（维也纳）的数据完全一致：单个HLA等位基因的频率、单倍型分布以及连锁不平衡值。配子关联研究表明，B和C基因（图距0.2厘摩）中有69.4%、A和C基因（0.6厘摩）中有36.9%，但A和B基因（0.8厘摩）中仅有23.2%的组合频率显著高于根据其频率预期的频率。从这些发现来看，MHC内的连锁不平衡似乎更多是由于进化时间短而非选择压力所致。文中还讨论了关于欧洲最常见单倍型A1,B8的一些观察结果。
