血管活性肠肽（VIP）是一种睡眠因子吗？

Is vasoactive intestinal polypeptide (VIP) a sleep factor?

作者信息

Drucker-Colín R, Bernal-Pedraza J, Fernández-Cancino F, Oksenberg A

出版信息

Peptides. 1984 Jul-Aug;5(4):837-40. doi: 10.1016/0196-9781(84)90032-9.

Abstract

Vasoactive intestinal peptide (VIP) was tested in order to determine its hypnogenic properties in cats. VIP was administered intraventricularly in doses of 10 and 100 ng and compared to Ringer controls. In addition the dose of 100 ng was tested in cats pretreated with 150 mg/kg of chloramphenicol (CAP). The results showed that the 100 ng dose of VIP had small but significant REM enhancing properties, but that it did not protect the animals from the specific REM inhibiting properties of CAP. The results suggest that VIP may participate in the regulation of REM sleep.

摘要

为了确定血管活性肠肽（VIP）对猫的催眠特性，对其进行了测试。以10纳克和100纳克的剂量将VIP脑室内给药，并与林格氏液对照组进行比较。此外，还对用150毫克/千克氯霉素（CAP）预处理的猫测试了100纳克的剂量。结果表明，100纳克剂量的VIP具有轻微但显著的快速眼动（REM）增强特性，但它并不能保护动物免受CAP特定的REM抑制特性的影响。结果表明，VIP可能参与REM睡眠的调节。