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阉牛对禁食和四氧嘧啶诱导的糖尿病的代谢反应。

Metabolic responses to fasting and alloxan-induced diabetes mellitus in steers.

作者信息

Smith S B, Prior R L

出版信息

Am J Vet Res. 1984 Sep;45(9):1829-34.

PMID:6497140
Abstract

To induce diabetes mellitus in 8 steers, they were fasted for 96 hours and given 110 mg of alloxan/kg of body weight (IV, in 1 dose) immediately before refeeding. Subsequently, 4 of the steers were treated with insulin (0.1 to 3 U/kg) to control hyperglycemia and 4 were not given insulin. Four control steers were fasted and refed. Fasting increased serum phosphorus, total protein, and bilirubin and decreased serum magnesium and potassium. Refeeding returned serum values of magnesium, potassium, total protein, and bilirubin toward base-line values, regardless of treatment group. However, serum phosphorus remained increased in steers with alloxan-induced diabetes and was not lowered by insulin injections. Sodium and chloride values were depressed in steers with alloxan-induced diabetes; these values remained significantly (P less than 0.05) lower than base-line values, even in steers given insulin. Fat infiltration was evident in the pancreas, liver, and to some extent, kidneys of steers with alloxan-induced diabetes, but was occasionally present in tissues of steers given insulin.

摘要

为使8头阉牛患糖尿病,先让它们禁食96小时,在重新喂食前立即静脉注射110毫克/千克体重的四氧嘧啶(一次性注射)。随后,4头阉牛用胰岛素治疗(0.1至3单位/千克)以控制高血糖,另外4头未注射胰岛素。4头对照阉牛进行禁食和重新喂食。禁食使血清磷、总蛋白和胆红素升高,血清镁和钾降低。重新喂食后,无论治疗组如何,镁、钾、总蛋白和胆红素的血清值都恢复到基线值。然而,四氧嘧啶诱导糖尿病的阉牛血清磷仍升高,胰岛素注射也未能使其降低。四氧嘧啶诱导糖尿病的阉牛钠和氯值降低;即使在注射胰岛素的阉牛中,这些值仍显著低于基线值(P<0.05)。四氧嘧啶诱导糖尿病的阉牛胰腺、肝脏以及一定程度上的肾脏有明显的脂肪浸润,但注射胰岛素的阉牛组织中偶尔也会出现。

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