Ghosal J, Biswas T, Ghosh A, Datta A G
Biochem Med. 1984 Aug;32(1):1-14. doi: 10.1016/0006-2944(84)90002-4.
Effect of Ep on [14C]acetate incorporation into different lipid fractions of RBC membranes in starved and phenylhydrazine-treated rats was studied. The incorporation was increased into both neutral and phospholipid fractions on Ep treatment to starved or phenylhydrazine-treated rats. A slight decrease in the ratio of neutral lipid to phospholipid was observed under the influence of Ep in starved rats (23%) or in phenylhydrazine-treated rats (36%). Incorporation of radioactivities into different phospholipid fractions of RBC membrane increased on Ep treatment to starved rats, whereas, the relative percentages of these phospholipids (except LPC) remained more or less unchanged under similar conditions. Phenylhydrazine treatment increased the relative percentage of PC and concomitantly decreased the percentage of Sph. Percentage composition of both these two phospholipids showed a tendency to return to their normal levels on administration of Ep to phenylhydrazine-treated rats. Ep decreased the sigma saturated/sigma unsaturated ratio of fatty acids in PE, PS, and PC of RBC membrane in starved rats. On the other hand, no significant change was observed in this ratio of fatty acids in the phospholipids except Sph of RBC membrane in the presence of phenylhydrazine and Ep. In Sph, the ratio went down under similar conditions.
研究了肾上腺素（Ep）对饥饿和苯肼处理大鼠红细胞膜不同脂质组分中[14C]乙酸掺入的影响。对饥饿或苯肼处理的大鼠给予Ep后，中性脂质和磷脂组分中的掺入量均增加。在Ep的影响下，饥饿大鼠（23%）或苯肼处理大鼠（36%）的中性脂质与磷脂的比例略有下降。对饥饿大鼠给予Ep后，红细胞膜不同磷脂组分中的放射性掺入量增加，而在类似条件下，这些磷脂（除溶血磷脂酰胆碱外）的相对百分比或多或少保持不变。苯肼处理增加了磷脂酰胆碱（PC）的相对百分比，同时降低了鞘磷脂（Sph）的百分比。对苯肼处理的大鼠给予Ep后，这两种磷脂的百分比组成都有恢复到正常水平的趋势。Ep降低了饥饿大鼠红细胞膜中磷脂酰乙醇胺（PE）、磷脂酰丝氨酸（PS）和PC中脂肪酸的饱和/不饱和比值。另一方面，在苯肼和Ep存在的情况下，除红细胞膜的Sph外，磷脂中脂肪酸的这一比值没有显著变化。在类似条件下，Sph中的比值下降。
