Sassoon C S, McAlpine S W, Tashkin D P, Baydur A, Quismorio F P, Mongan E S
Arthritis Rheum. 1984 Nov;27(11):1218-26. doi: 10.1002/art.1780271103.
To evaluate the possible relationship between rheumatoid arthritis (RA) and airways dysfunction independent of cigarette smoking, we studied 19 lifetime nonsmokers with RA and 47 healthy nonsmokers. Ten tests of small airways function were administered to the subjects. In addition, diffusing capacity and static lung compliance were measured, and upstream airway conductance at mid-to-low lung volumes was calculated. Mean values were not significantly lower in the RA group than in the control group in any of the tests of small airways function. Three of the 19 (16%) patients with RA versus 15 of the 47 (32%) control subjects had abnormal findings on greater than 2 tests of small airways function (P greater than 0.1). Although mean diffusing capacity and static lung compliance were both within normal limits in each group, the former tended to be lower, while the latter was significantly lower, in the RA subjects. We conclude that airways dysfunction in RA, if present, is probably related to factors other than the underlying disease; if an association between RA and small airways abnormality is present in some patients, its prevalence is too small to have been detected in our sample.
为了评估类风湿性关节炎（RA）与独立于吸烟的气道功能障碍之间的可能关系，我们研究了19名终生不吸烟的类风湿性关节炎患者和47名健康的不吸烟者。对受试者进行了10项小气道功能测试。此外，还测量了弥散能力和静态肺顺应性，并计算了中低肺容量时的上游气道传导率。在任何小气道功能测试中，RA组的平均值均未显著低于对照组。19名（16%）类风湿性关节炎患者中有3名与47名（32%）对照受试者中有15名在超过2项小气道功能测试中有异常结果（P>0.1）。虽然每组的平均弥散能力和静态肺顺应性均在正常范围内，但RA受试者中前者往往较低，而后者显著较低。我们得出结论，RA中的气道功能障碍（如果存在）可能与潜在疾病以外的因素有关；如果某些患者中RA与小气道异常之间存在关联，其患病率太小以至于在我们的样本中未被检测到。
