神经元的躯体分流电缆模型。
The somatic shunt cable model for neurons.
作者信息
Durand D
出版信息
Biophys J. 1984 Nov;46(5):645-53. doi: 10.1016/S0006-3495(84)84063-1.
Abstract
The derivation of the equations for an electrical model of nerve cells is presented. The model consists of an equivalent cylinder, a lumped somatic impedance, and a variable shunt at the soma. This shunt was introduced to take into account the fast voltage decays observed following the injections of current pulses in some motoneurons and hippocampal granule cells that could not be explained by existing models. The shunt can be interpreted either by penetration damage with the electrode or by a lower membrane specific resistance at the soma than in the dendrites. A solution of the model equations is presented that allows the estimation of the electrotonic length L, the membrane time constant tau m, the dendritic dominance ratio rho, and the shunt parameter epsilon, based only on the measurement of the first two coefficients and time constants in the multiexponential voltage response to injected current pulses.
摘要
本文介绍了神经细胞电模型方程的推导。该模型由一个等效圆柱体、一个集总躯体阻抗和躯体处的可变分流组成。引入这个分流是为了考虑在一些运动神经元和海马颗粒细胞中注入电流脉冲后观察到的快速电压衰减，而现有模型无法解释这种现象。分流可以解释为电极造成的穿透损伤，或者是躯体处的膜比树突处具有更低的比电阻。给出了模型方程的一个解，该解仅基于对注入电流脉冲的多指数电压响应中的前两个系数和时间常数的测量，就能估计电紧张长度L、膜时间常数τm、树突优势比ρ和分流参数ε。
相似文献
1
The somatic shunt cable model for neurons.神经元的躯体分流电缆模型。
Biophys J. 1984 Nov;46(5):645-53. doi: 10.1016/S0006-3495(84)84063-1.
2
Electrotonic length estimates in neurons with dendritic tapering or somatic shunt.具有树突逐渐变细或体细胞分流的神经元中的电紧张长度估计。
J Neurophysiol. 1992 Oct;68(4):1421-37. doi: 10.1152/jn.1992.68.4.1421.
3
Techniques for obtaining analytical solutions to the multicylinder somatic shunt cable model for passive neurones.获取被动神经元多圆柱体细胞旁道电缆模型解析解的技术。
Biophys J. 1992 Aug;63(2):350-65. doi: 10.1016/S0006-3495(92)81631-4.
4
Electrotonic parameters of rat dentate granule cells measured using short current pulses and HRP staining.使用短电流脉冲和辣根过氧化物酶染色测量大鼠齿状颗粒细胞的电紧张参数。
J Neurophysiol. 1983 Nov;50(5):1080-97. doi: 10.1152/jn.1983.50.5.1080.
5
White noise approach for estimating the passive electrical properties of neurons.用于估计神经元被动电学特性的白噪声方法。
J Neurophysiol. 1996 Nov;76(5):3442-50. doi: 10.1152/jn.1996.76.5.3442.
6
Estimation of electrotonic parameters of neurons using an inverse Fourier transform technique.使用逆傅里叶变换技术估计神经元的电紧张参数。
IEEE Trans Biomed Eng. 1992 May;39(5):493-501. doi: 10.1109/10.135543.
7
Tuberal supraoptic neurons--II. Electrotonic properties.结节上视神经元——II. 电紧张特性
Neuroscience. 1990;38(2):485-94. doi: 10.1016/0306-4522(90)90044-5.
8
Nonequivalent cylinder models of neurons: interpretation of voltage transients generated by somatic current injection.神经元的非等效圆柱模型：体细胞电流注入产生的电压瞬变的解释
J Neurophysiol. 1988 Jul;60(1):125-48. doi: 10.1152/jn.1988.60.1.125.
9
10
Electrotonic parameters of neurons following chronic ethanol consumption.
J Neurophysiol. 1985 Oct;54(4):807-17. doi: 10.1152/jn.1985.54.4.807.
引用本文的文献
1
A spectral element method with adaptive segmentation for accurately simulating extracellular electrical stimulation of neurons.一种具有自适应分割的谱元法，用于精确模拟神经元的细胞外电刺激。
Med Biol Eng Comput. 2017 May;55(5):823-831. doi: 10.1007/s11517-016-1558-x. Epub 2016 Aug 19.
2
Computational Models Describing Possible Mechanisms for Generation of Excessive Beta Oscillations in Parkinson's Disease.描述帕金森病中产生过度β振荡可能机制的计算模型
PLoS Comput Biol. 2015 Dec 18;11(12):e1004609. doi: 10.1371/journal.pcbi.1004609. eCollection 2015 Dec.
3
Somato-dendritic morphology and dendritic signal transfer properties differentiate between fore- and hindlimb innervating motoneurons in the frog Rana esculenta.躯体-树突形态和树突信号传递特性可区分青蛙 Rana esculenta 前肢和后肢传入运动神经元。
BMC Neurosci. 2012 Jun 18;13:68. doi: 10.1186/1471-2202-13-68.
4
An analytic solution of the cable equation predicts frequency preference of a passive shunt-end cylindrical cable in response to extracellular oscillating electric fields.电缆方程的解析解预测了被动分流端圆柱电缆对细胞外振荡电场的频率偏好。
Biophys J. 2010 Feb 17;98(4):524-33. doi: 10.1016/j.bpj.2009.10.041.
5
Subthreshold dendritic signal processing and coincidence detection in dentate gyrus granule cells.齿状回颗粒细胞中的阈下树突信号处理与巧合检测
J Neurosci. 2007 Aug 1;27(31):8430-41. doi: 10.1523/JNEUROSCI.1787-07.2007.
6
Developmental regulation of active and passive membrane properties in rat vibrissa motoneurones.大鼠触须运动神经元主动和被动膜特性的发育调控
J Physiol. 2004 Apr 1;556(Pt 1):203-19. doi: 10.1113/jphysiol.2003.060087. Epub 2004 Feb 6.
7
Ionic mechanisms underlying spontaneous CA1 neuronal firing in Ca2+-free solution.无钙溶液中CA1神经元自发放电的离子机制。
Biophys J. 2003 Mar;84(3):2099-111. doi: 10.1016/S0006-3495(03)75017-6.
8
An estimator for the electrotonic size of neurons independent of charge equalization time constants.一种与电荷平衡时间常数无关的神经元电紧张大小的估计方法。
J Comput Neurosci. 2002 Jan-Feb;12(1):27-38. doi: 10.1023/a:1014990012867.
9
Parameter estimation methods for single neuron models.单神经元模型的参数估计方法。
J Comput Neurosci. 2000 Nov-Dec;9(3):215-36. doi: 10.1023/a:1026531603628.
10
Comparison of alternative designs for reducing complex neurons to equivalent cables.将复杂神经元简化为等效电缆的替代设计比较。
J Comput Neurosci. 2000 Jul-Aug;9(1):31-47. doi: 10.1023/a:1008934327204.
本文引用的文献
1
Branching dendritic trees and motoneuron membrane resistivity.分支树突状结构与运动神经元膜电阻
Exp Neurol. 1959 Nov;1:491-527. doi: 10.1016/0014-4886(59)90046-9.
2
Epileptiform burst afterhyperolarization: calcium-dependent potassium potential in hippocampal CA1 pyramidal cells.癫痫样爆发后超极化：海马CA1锥体神经元中的钙依赖性钾电流
Science. 1980 Dec 5;210(4474):1122-4. doi: 10.1126/science.7444438.
3
Steady-state electrotonic analysis of intracellularly stained hippocampal neurons.细胞内染色海马神经元的稳态电紧张分析
J Neurophysiol. 1980 Jul;44(1):184-99. doi: 10.1152/jn.1980.44.1.184.
4
Passive electrical constants in three classes of hippocampal neurons.三类海马神经元的被动电学常数
J Neurophysiol. 1981 Oct;46(4):812-27. doi: 10.1152/jn.1981.46.4.812.
5
A late increase in potassium conductance follows synaptic stimulation of granule neurons of the dentate gyrus.齿状回颗粒神经元的突触刺激后会出现钾电导的延迟增加。
Neurosci Lett. 1982 Apr 26;29(3):243-8. doi: 10.1016/0304-3940(82)90324-x.
6
Decreased neuronal inhibition in vitro after long-term administration of ethanol.
Science. 1984 Jun 22;224(4655):1359-61. doi: 10.1126/science.6328654.
7
Evidence for two types of afterhyperpolarization in CA1 pyramidal cells in the hippocampus.海马体CA1锥体神经元中两种超极化后电位类型的证据。
Brain Res. 1981 Feb 16;206(2):462-8. doi: 10.1016/0006-8993(81)90548-5.
8
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons.海马神经元重复放电后会出现钙激活超极化。
J Neurophysiol. 1980 Feb;43(2):409-19. doi: 10.1152/jn.1980.43.2.409.
9
Electrotonic parameters of rat dentate granule cells measured using short current pulses and HRP staining.使用短电流脉冲和辣根过氧化物酶染色测量大鼠齿状颗粒细胞的电紧张参数。
J Neurophysiol. 1983 Nov;50(5):1080-97. doi: 10.1152/jn.1983.50.5.1080.
10
Modelling the postsynaptic location and magnitude of tonic conductance changes resulting from neurotransmitters or drugs.
Neuroscience. 1981;6(5):839-46. doi: 10.1016/0306-4522(81)90166-4.
Zotero 插件