Uza G, Pavel O, Kovacs A, Uza D, Vlaicu R
Clin Exp Hypertens A. 1984;6(8):1415-29. doi: 10.3109/10641968409044059.
Serum concentration of Na, K, Ca, Mg and inorganic phosphate as well as serum levels of Zn and Cu were determined in control subjects and in patients with essential arterial hypertension (EAH) divided according to the stage of the disease. No significant differences were found between the serum mean levels of Na, K, Ca, Mg, Zn and Cu in controls and in patients with EAH. A significant decrease of the serum Zn was noted in the third stage of EAH. A number of cases with hypomagnesemia and/or hypopotassemia probably caused by a long term uncontrolled therapy was also detected. The concentration of inorganic phosphate was significantly lower in patients with EAH associated with overweight than in hypertensive patients with normal body weight and in controls. It is considered that a sustained study of the complex interrelationship between electrolyte interaction and the functional aspects of the arterial wall could still contribute to a better understanding of pathogenic aspects of EAH and of its complications including those subsequent to modern diuretic therapy.
在健康对照者以及根据疾病阶段划分的原发性高血压（EAH）患者中，测定了血清钠、钾、钙、镁和无机磷酸盐的浓度以及血清锌和铜的水平。在对照者和EAH患者中，血清钠、钾、钙、镁、锌和铜的平均水平未发现显著差异。在EAH第三阶段，血清锌显著降低。还检测到一些可能由长期未控制治疗导致的低镁血症和/或低钾血症病例。与超重相关的EAH患者的无机磷酸盐浓度显著低于体重正常的高血压患者和对照者。人们认为，持续研究电解质相互作用与动脉壁功能方面之间的复杂相互关系，仍有助于更好地理解EAH的发病机制及其并发症，包括现代利尿剂治疗后的并发症。
