Uza G, Vlaicu R
Institute of Hygiène and Public Health, Cluj-Napoca, Romania.
Biol Trace Elem Res. 1989 Jun;20(3):197-206. doi: 10.1007/BF02917435.
The serum concentration of Zn and Cu were determined in 126 controls and 160 patients with atherosclerosis obliterans (AO) and 53 patients with thromboangiitis obliterans (TO). The concentration of serum Zn decreases with age both in controls and patients with AO in all the evolutive stages of the disease. In patients with TO, the concentration of serum Zn shows no correlation with age. The significantly lower values of serum Zn in controls and patients with AO over 61 yr than those below this age is attributed to the decreased Zn supply, especially to some individual cellular abnormalities. The values of serum Cu are higher in patients with AO and TO than in controls irrespective of the evolutive stage of the disease. This was related to cigarette smoking and inflammation. The Zn/Cu ratio in the serum is below 1 in patients with AO and TO and in controls over 61-yr-old. The pathogenetic role of this ratio in atherosclerosis and inflammation still remains a controversial question.
测定了126例对照者、160例闭塞性动脉硬化症（AO）患者和53例血栓闭塞性脉管炎（TO）患者的血清锌和铜浓度。在疾病的所有发展阶段，对照组和AO患者的血清锌浓度均随年龄降低。在TO患者中，血清锌浓度与年龄无关。61岁及以上的对照组和AO患者血清锌值显著低于该年龄以下者，这归因于锌供应减少，尤其是一些个体细胞异常。无论疾病处于何种发展阶段，AO和TO患者的血清铜值均高于对照组。这与吸烟和炎症有关。AO和TO患者以及61岁以上对照组的血清锌/铜比值均低于1。该比值在动脉粥样硬化和炎症中的致病作用仍是一个有争议的问题。
