Shelby M D, Stasiewicz S
Environ Mutagen. 1984;6(6):871-8. doi: 10.1002/em.2860060613.
Studies to determine the performance of short-term tests (STT) in predicting chemical carcinogenicity are frequently characterized by a poor representation of noncarcinogens among the test chemicals. As a result, the performance of several STT is well characterized with carcinogenic chemicals, but the ability of the tests to discriminate between carcinogens and noncarcinogens is largely unknown because of the shortage of test results for noncarcinogens. A list of 70 chemicals that have been tested by the National Cancer Institute or the National Toxicology Program in long-term rodent carcinogenicity studies and that have yielded no evidence of cancer induction in male and female rats and mice is presented. The list helps document the shortage of STT results of noncarcinogens and provides a potential source of chemicals for consideration in future studies designed to assess the ability of STT to predict chemical carcinogenicity.
旨在确定短期试验（STT）在预测化学物质致癌性方面表现的研究，其特点往往是受试化学物质中，非致癌物的代表性不足。因此，几种短期试验针对致癌化学物质的表现已得到充分表征，但由于非致癌物的试验结果短缺，这些试验区分致癌物和非致癌物的能力在很大程度上仍不明确。本文列出了70种已在美国国家癌症研究所或国家毒理学计划的长期啮齿动物致癌性研究中进行过测试的化学物质，这些物质在雄性和雌性大鼠及小鼠中均未产生致癌证据。该列表有助于记录非致癌物短期试验结果的短缺情况，并为未来旨在评估短期试验预测化学物质致癌性能力的研究提供了潜在的化学物质来源以供考虑。
