Tyler T R
Environ Health Perspect. 1984 Aug;57:185-91. doi: 10.1289/ehp.8457185.
The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. In evaluating the hazard that this chemical may pose to man, consideration has been given to likely routes of exposure and its irritant properties. It is concluded that the available information continues to support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm.
对乙二醇单丁醚的急性和亚慢性毒性的现有信息进行了综述。已从剂量反应关系以及包括人类在内的各种动物物种对该化学品影响的敏感性角度，审视了动物研究数据。鉴于最近对其他化学相关二醇醚的研究结果，已特别关注对血液和睾丸组织可能产生的不良影响。在评估该化学品可能对人类构成的危害时，已考虑了可能的接触途径及其刺激性。结论是，现有信息继续支持美国政府工业卫生学家会议（ACGIH）目前规定的时间加权平均阈限值（TWA）为25 ppm，短时间接触阈限值（STEL）为75 ppm。
