Miller R R, Carreon R E, Young J T, McKenna M J
Fundam Appl Toxicol. 1982 Jul-Aug;2(4):158-60. doi: 10.1016/s0272-0590(82)80039-0.
Male Fischer 344 rats were given eight daily doses of 0, 30, 100 or 300 mg/kg methoxyacetic acid by gavage. The high dose resulted in decreased body weight, severe degeneration of testicular germinal epithelium, decreased size of the thymus with depletion of thymic cortical lymphoid elements, and reductions in bone marrow cellularity resulting in depressions of red blood cell counts, hemoglobin concentration, packed cell volume, and white blood cell counts. Some of these observations were apparent to a lesser degree in rats given 100 mg/kg. The low dose produced no apparent effects during the course of the study. These toxicological properties of methoxyacetic acid are remarkably similar to ethylene glycol monomethyl ether (EGME), and the adverse effects of EGME in rats are probably the result of in vivo bioactivation of EGME to methoxyacetic acid.
给雄性Fischer 344大鼠每日经口灌胃给予8次剂量为0、30、100或300mg/kg的甲氧基乙酸。高剂量导致体重减轻、睾丸生精上皮严重退化、胸腺体积减小且胸腺皮质淋巴样细胞减少，以及骨髓细胞数量减少，导致红细胞计数、血红蛋白浓度、血细胞比容和白细胞计数降低。在给予100mg/kg的大鼠中，其中一些观察结果在较小程度上也很明显。低剂量在研究过程中未产生明显影响。甲氧基乙酸的这些毒理学特性与乙二醇单甲醚（EGME）非常相似，并且EGME对大鼠的不良影响可能是EGME在体内生物活化成甲氧基乙酸的结果。
