早产儿中的白细胞介素-1β和白细胞介素-3样活性
IL-1 beta and IL-3-like activity in preterm infants.
作者信息
Bessler H, Sirota L, Notti I, Dulitzky F, Djaldetti M
机构信息
Haematology Research Laboratory, Hasharon Hospital, Golda Medical Centre, Tel Aviv University Medical School, Petah-Tiqva, Israel.
出版信息
Clin Exp Immunol. 1993 Feb;91(2):320-4. doi: 10.1111/j.1365-2249.1993.tb05902.x.
The capacity of peripheral blood mononuclear cells (PBMC) of preterm neonates to release IL-1 beta and IL-3-like activity (IL-3-LA) has been investigated. In the present study it was found that this capacity is significantly lower than that of their mothers and of control adults. In addition, the results showed that preterm serum has a lower stimulatory effect on IL-1 beta production and an inhibitory effect on IL-3-LA secretion by PBMC of adult controls, in comparison with maternal and adult sera. These findings suggest an additional feedback mechanism for control of haematopoiesis in premature neonates. It is possible that the lower production of IL-1 beta and IL-3-LA may be involved in the increased susceptibility to infections of preterm newborns.
对早产儿外周血单个核细胞（PBMC）释放白细胞介素-1β（IL-1β）和白细胞介素-3样活性（IL-3-LA）的能力进行了研究。在本研究中发现，这种能力显著低于其母亲和对照成年人。此外，结果表明，与母亲和成年人血清相比，早产血清对成年对照PBMC的IL-1β产生具有较低的刺激作用，对IL-3-LA分泌具有抑制作用。这些发现提示了一种用于控制早产儿造血的额外反馈机制。IL-1β和IL-3-LA产生较低可能参与了早产新生儿感染易感性增加的过程。
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