Reeves J D, Yip R, Kiley V A, Dallman P R
J Pediatr. 1984 Dec;105(6):874-9. doi: 10.1016/s0022-3476(84)80069-4.
In this study of 467 healthy term infants seen for routine 1-year health maintenance examination, we determined the influence of mild prior infection on the concentration of hemoglobin and other laboratory evidence of iron deficiency. In addition we studied the Hgb response in 261 infants randomized to receive a 3-month course of treatment with either iron or placebo. Infants who had had one or more clinic visits because of infection during the previous 3 months or who were reported as not being entirely well during the past month or who had an elevated sedimentation rate were more likely to have anemia or "low normal" Hgb, higher erythrocyte protoporphyrin and serum ferritin values, and lower serum iron concentration than infants who had been well. Hgb response greater than or equal to 1 gm/dl after iron treatment occurred more commonly in infants who had had prior visits because of infection. The results indicate that upper respiratory and other mild antecedent infections commonly predispose to iron deficiency (probably because of a decrease in iron absorption).
在这项针对467名前来进行常规1岁健康维护检查的足月健康婴儿的研究中，我们确定了既往轻度感染对血红蛋白浓度及其他缺铁实验室证据的影响。此外，我们对261名随机接受为期3个月铁剂或安慰剂治疗的婴儿的血红蛋白反应进行了研究。在过去3个月内因感染而有过一次或多次门诊就诊、或在过去一个月内被报告身体并非完全健康、或血沉率升高的婴儿，比健康婴儿更有可能出现贫血或“低正常”血红蛋白水平、更高的红细胞原卟啉和血清铁蛋白值，以及更低的血清铁浓度。在因感染而有过门诊就诊的婴儿中，铁剂治疗后血红蛋白反应大于或等于1克/分升的情况更为常见。结果表明，上呼吸道感染和其他轻度既往感染通常易导致缺铁（可能是由于铁吸收减少）。
