Ali F M, Sarper R, Malveaux E J, Faraj B A
J Pharm Sci. 1984 Oct;73(10):1363-5. doi: 10.1002/jps.2600731009.
The synthesis and biodistribution properties of 99mTc-labeled N-substituted tyramine, [N-(4-hydroxyphenethyl)iminodiacetic acid] are described. Tissue distribution studies in rats were indicative of high hepatic and kidney extraction, accompanied by rapid plasma and urinary clearance and minimal biliary excretion. These findings were substantiated by organ image analysis. The preliminary data indicate that this labeled material may represent a new class of radiopharmaceuticals for the evaluation of hepatic and renal functions.
描述了99mTc标记的N-取代酪胺，即[N-(4-羟基苯乙基)亚氨基二乙酸]的合成及生物分布特性。在大鼠身上进行的组织分布研究表明，肝脏和肾脏摄取率高，同时血浆和尿液清除迅速，胆汁排泄极少。这些发现通过器官图像分析得到了证实。初步数据表明，这种标记物可能代表了一类用于评估肝脏和肾脏功能的新型放射性药物。
