Perman J A, Barr R G, Watkins J B
J Pediatr. 1978 Jul;93(1):17-22. doi: 10.1016/s0022-3476(78)80592-7.
To assess whether malabsorption of specific sugars is easily detected in a pediatric population by interval measurement of breath hydrogen excretion, hydrogen concentration was determined following administration of oral sucrose to six sucrose-intolerant children with congenital sucrase-isomaltase deficiency and in 16 sucrose-tolerant control subjects. Breath samples were collected by means of a newly devised nasal prong technique not requiring active patient cooperation and suitable for use in all age groups. Breath hydrogen concentrations obtained by samples collected by this method correlated highly (r = 0.94) with the previously validated modified Haldane-Priestley tube method for sampling alveolar air. Identification of sucrose-intolerant individuals was achieved on the basis of hydrogen excretion: peak values, expressed as parts per million above baseline (deltappm), equalled 114 +/- 63 (mean +/- SD) versus 2.4 +/- 3.6 deltappm in control subjects (P = 0.007). Best discrimination between the groups occurred at 90 minutes postingestion. The findings validate this simple method for collection of expired air and demonstrate that breath hydrogen determination permits the noninvasive detection of sucrose malabsorption in children.
为了评估通过间歇性测量呼气氢排泄量是否能在儿科人群中轻松检测出特定糖类的吸收不良，我们对6名患有先天性蔗糖酶 - 异麦芽糖酶缺乏症的蔗糖不耐受儿童和16名蔗糖耐受的对照受试者口服蔗糖后测定了氢浓度。呼气样本通过一种新设计的鼻叉技术采集，该技术无需患者主动配合，适用于所有年龄组。用这种方法采集的样本所获得的呼气氢浓度与先前验证的用于采集肺泡气的改良霍尔丹 - 普里斯特利管法高度相关（r = 0.94）。根据氢排泄量来识别蔗糖不耐受个体：峰值以高于基线的百万分率（deltappm）表示，在蔗糖不耐受儿童中为114±63（平均值±标准差），而在对照受试者中为2.4±3.6 deltappm（P = 0.007）。两组之间的最佳区分出现在摄入后90分钟。这些发现验证了这种简单的呼气采集方法，并表明测定呼气氢能够无创检测儿童的蔗糖吸收不良。
