Davidson G P, Robb T A
Med J Aust. 1983 Jul 9;2(1):29-32. doi: 10.5694/j.1326-5377.1983.tb142082.x.
Eighty-one breath hydrogen tests were performed in 72 children who were investigated either because of chronic diarrhoea or recurrent abdominal pain, or because they were relatives of patients with congenital sucrase-isomaltase deficiency. The results of tests on 16 patients were positive (sucrase-isomaltase deficiency, seven patients; secondary sucrose malabsorption, nine patients). Hydrogen production was higher in patients with sucrase-isomaltase deficiency (mean, 96 ppm; range, 20 ppm to 432ppm) than in those with secondary sucrose malabsorption (mean, 21 ppm; range, 12ppm to 51ppm). All patients with positive test results responded to sucrose restriction, and those with secondary malabsorption subsequently became well. The breath hydrogen test is a sensitive, non-invasive method for detecting sucrose malabsorption, whether due to a primary deficiency or secondary to other bowel disorders. Guidelines for improving the accuracy and reproducibility of the breath hydrogen test are discussed.
对72名儿童进行了81次呼气氢试验，这些儿童接受调查的原因包括慢性腹泻、反复腹痛，或者是先天性蔗糖酶-异麦芽糖酶缺乏症患者的亲属。16例患者的检测结果呈阳性（蔗糖酶-异麦芽糖酶缺乏症7例；继发性蔗糖吸收不良9例）。蔗糖酶-异麦芽糖酶缺乏症患者的产氢量（平均96 ppm；范围20 ppm至432 ppm）高于继发性蔗糖吸收不良患者（平均21 ppm；范围12 ppm至51 ppm）。所有检测结果呈阳性的患者对限制蔗糖摄入均有反应，继发性吸收不良的患者随后病情好转。呼气氢试验是一种检测蔗糖吸收不良的敏感、无创方法，无论其是由原发性缺乏还是继发于其他肠道疾病引起。本文讨论了提高呼气氢试验准确性和可重复性的指南。
