Douwes A C, Fernandes J, Jongbloed A A
Acta Paediatr Scand. 1980 Jan;69(1):79-82. doi: 10.1111/j.1651-2227.1980.tb07034.x.
An oral sucrose tolerance test was performed in a group of 103 children, aged between 3 months and 15 years because of episodic diarrhea and/or abdominal pains. Sucrose malabsorption defined as an abnormal increase in expired hydrogen, was found in only 3 children who suffered from congenital sucrase-isomaltase deficiency. This 1% incidence of sucrose malabsorption was lower than the incidence of lactose malabsorption found in this group (33%). Mean rise in blood glucose during the sucrose test was higher (3.4 +/- 1.4 vs. 2.4 +/- 1.2 mmol/l, p less than 0.0001) and the occurrence of false flat blood glucose curves was lower (3% vs. 12.8%, p less than 0.05) than during the lactose test. These findings are consistent with the higher sucrase activity in the small bowel mucosa compared to lactase. In contrast to the lactose tolerance test, sucrose tolerance test should not be used as a screening procedure for secondary disaccharidase deficiency in children.
对一组103名年龄在3个月至15岁之间、因发作性腹泻和/或腹痛的儿童进行了口服蔗糖耐量试验。仅在3名患有先天性蔗糖酶-异麦芽糖酶缺乏症的儿童中发现蔗糖吸收不良，表现为呼出氢气异常增加。这种1%的蔗糖吸收不良发生率低于该组中乳糖吸收不良的发生率（33%）。蔗糖试验期间血糖的平均升高幅度更高（3.4±1.4与2.4±1.2 mmol/l，p<0.0001），与乳糖试验相比，血糖曲线出现假性平坦的发生率更低（3%对12.8%，p<0.05）。这些发现与小肠黏膜中蔗糖酶活性高于乳糖酶一致。与乳糖耐量试验不同，蔗糖耐量试验不应作为儿童继发性二糖酶缺乏症的筛查方法。
