Pearson A E, Steel G G
Radiother Oncol. 1984 Jun;2(1):49-55. doi: 10.1016/s0167-8140(84)80038-9.
The importance of timing of drug administration in combination with pelvic irradiation on animal lethality was investigated in male CBA mice. The chemotherapeutic agents cyclophosphamide, cytosine arabinoside, 5-fluorouracil, methotrexate, cis-dichlorodiammine platinum (II), adriamycin, CCNU, VP-16 and bleomycin were administered at various times up to 2 weeks before and 2 weeks after pelvic irradiation (4 weeks before and after in the case of cyclophosphamide) of unanaesthetised mice and the LD50/30 days and dose enhancement factors determined. The results indicate a potentiation of radiation-induced damage when drugs are given near to the time of irradiation, particularly at about 3 days post-irradiation.
在雄性CBA小鼠中研究了药物给药时间与盆腔照射联合对动物致死率的影响。在未麻醉小鼠盆腔照射前2周和照射后2周（环磷酰胺为照射前4周和照射后4周）的不同时间给予化疗药物环磷酰胺、阿糖胞苷、5-氟尿嘧啶、甲氨蝶呤、顺二氯二氨铂（II）、阿霉素、洛莫司汀、依托泊苷和博来霉素，并测定LD50/30天和剂量增强因子。结果表明，当药物在接近照射时间给药时，尤其是在照射后约3天给药时，辐射诱导的损伤会增强。
