[Interaction of the pentosephosphate cycle and nucleic acid metabolism during the healing of experimental fractures].

In healing of rat femur fracture activity of glucose-6-phosphate dehydrogenase and total content of nucleic acids were increased in callus, reaching the maximal value within 1 week after the fracture and decreased down to the level observed in intact controls within 10-15 weeks. The enzymatic activity correlated closely with the content of nucleic acids. The data obtained suggest that the tissue reparation depends considerably on the activity of pentose phosphate shunt at the initial periods of healing, which has to be taken into consideration in studies on stimulation of consolidation process.