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源自人睾丸肿瘤转移灶的上皮细胞产生逆转录病毒的形态学证据。

Morphologic evidence for retrovirus production by epithelial cells derived from a human testicular tumor metastasis.

作者信息

Bronson D L, Ritzi D M, Fraley E E, Dalton A J

出版信息

J Natl Cancer Inst. 1978 Jun;60(6):1305-8. doi: 10.1093/jnci/60.6.1305.

DOI:10.1093/jnci/60.6.1305
PMID:650698
Abstract

Ultrastructural examination of primary and subcultured epithelial cells established in vitro from an abdominal metastasis of a human testicular tumor revealed particles with the morphology of retroviruses. These structures, found only after extensive scanning of the cells, were observed budding from microvilli and from the outer cell membrane and as extracellular particles. Production of these virus particles was stimulated by the incubation of cells in culture medium containing 5-iodo-2'-deoxyuridine and dexamethasone.

摘要

对从一名人类睾丸肿瘤腹部转移灶体外建立的原代和传代培养上皮细胞进行超微结构检查,发现了具有逆转录病毒形态的颗粒。这些结构仅在对细胞进行广泛扫描后才发现,观察到它们从微绒毛和细胞外膜出芽,并作为细胞外颗粒存在。在含有5-碘-2'-脱氧尿苷和地塞米松的培养基中培养细胞可刺激这些病毒颗粒的产生。

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Morphologic evidence for retrovirus production by epithelial cells derived from a human testicular tumor metastasis.源自人睾丸肿瘤转移灶的上皮细胞产生逆转录病毒的形态学证据。
J Natl Cancer Inst. 1978 Jun;60(6):1305-8. doi: 10.1093/jnci/60.6.1305.
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Induction of retrovirus particles in human testicular tumor (Tera-1) cell cultures: an electron microscopic study.人睾丸肿瘤(Tera-1)细胞培养中逆转录病毒颗粒的诱导:一项电子显微镜研究。
J Natl Cancer Inst. 1979 Aug;63(2):337-9.
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