D-氨基酸对β-内酰胺抗生素引起的生长抑制和裂解的保护作用。
Protection by D-amino acids against growth inhibition and lysis caused by beta-lactam antibiotics.
作者信息
Tuomanen E, Tomasz A
出版信息
Antimicrob Agents Chemother. 1984 Sep;26(3):414-6. doi: 10.1128/AAC.26.3.414.
Abstract
D-Isomers of several amino acids completely protected growing cultures of Escherichia coli against all antibacterial effects of beta-lactam antibiotics up to approximately two to three times the MICs of the antibiotics. L-Isomers of amino acids were ineffective. Protection depended on the concentration and time of addition of the D-amino acids. This appears to be the first demonstration of natural products capable of reversing the antibacterial effects of beta-lactam antibiotics.
摘要
几种氨基酸的D-异构体可完全保护大肠杆菌生长培养物免受β-内酰胺类抗生素的所有抗菌作用，保护程度可达抗生素最低抑菌浓度（MIC）的约两到三倍。氨基酸的L-异构体则无效。保护作用取决于D-氨基酸的添加浓度和时间。这似乎是首次证明天然产物能够逆转β-内酰胺类抗生素的抗菌作用。
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