肝癌染色质抗原的核内定位在肝染色质中未被检测到

[Intranuclear localization of hepatoma chromatin antigens not detected in liver chromatin].

作者信息

Nanazashvili M G, Serykh M M, Ermekova V M

出版信息

Eksp Onkol. 1984;6(5):39-42.

Abstract

Localization of malignant cell antigens which are not detected in the liver chromatin was investigated by antibodies to chromatin of Zajdela ascite hepatoma and solid hepatoma 27. Antibodies to chromatin of Zajdela ascite hepatoma do not interact with nuclear matrix of both hepatoma and liver cells. Zajdela ascite hepatoma and solid hepatoma 27 chromatin regions hypersensitive to DNase I and endogenous Mg2+-dependent nuclease are enriched with immunogenic proteins. Antibodies to hepatoma chromatins pretreated with liver chromatin show that hepatoma chromatin antigens which are not detected in liver chromatin are localized in chromatin regions hypersensitive to nucleases but are absent (or scanty) in actively transcribed regions.

摘要

通过针对Zajdela腹水肝癌和实体肝癌27染色质的抗体，研究了在肝脏染色质中未检测到的恶性细胞抗原的定位。Zajdela腹水肝癌染色质抗体不与肝癌细胞和肝细胞的核基质相互作用。对DNase I和内源性Mg2+依赖性核酸酶敏感的Zajdela腹水肝癌和实体肝癌27染色质区域富含免疫原性蛋白。用肝脏染色质预处理的肝癌染色质抗体表明，在肝脏染色质中未检测到的肝癌染色质抗原位于对核酸酶敏感的染色质区域，但在活跃转录区域不存在（或稀少）。

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