Nanazashvili M G, Ermekova V M, Serykh M M, Umanskiĭ S R
Eksp Onkol. 1984;6(3):38-42.
Differences in antigenic structure of chromatin from normal and tumour cells were studied using rabbit antibodies against chromatin of the rat liver, Zaidela ascite hepatoma and solid hepatoma 27 cells. It is shown that carcinogenesis is accompanied by loss of a part of normal liver antigens. All the antigens which are not indicated in solid hepatoma were not detected in ascite tumour too. The latter is deficient in some antigens common for the normal liver and solid hepatoma cells. Chromatin of both hepatomas contains antigens which are not detected in liver chromatin. Hepatoma 27 contains also antigens detected in this tumour only. At least some antigens of tumour cells are not found in regenerating liver and in liver cells of newborn rats. Antigenic properties of liver cells chromatin in old (30 months) rats approach to those of hepatoma cells chromatin.
利用兔抗大鼠肝脏、扎伊德拉腹水肝癌和实体肝癌27细胞染色质的抗体，研究了正常细胞和肿瘤细胞染色质抗原结构的差异。结果表明，致癌过程伴随着部分正常肝脏抗原的丧失。实体肝癌中未显示的所有抗原在腹水肿瘤中也未检测到。后者缺乏一些正常肝脏和实体肝癌细胞共有的抗原。两种肝癌的染色质都含有在肝脏染色质中未检测到的抗原。肝癌27还含有仅在该肿瘤中检测到的抗原。在再生肝脏和新生大鼠的肝细胞中未发现肿瘤细胞的至少一些抗原。老年（30个月）大鼠肝细胞染色质的抗原特性接近肝癌细胞染色质的抗原特性。
