Gershun V A
Neoplasma. 1981;28(1):27-34.
A comparative study of the antigenic properties of the nonhistone protein (NHP)-DNA complexes, isolated from liver and kidney chromatin of intact rats and from Zajdela hepatoma cells, revealed in the latter the presence of an antigenic component characteristic of kidney chromatin but never occurring in the liver chromatin of intact rats. A similar antigenic component is found in rat liver 4--7 days following a single injection of the hepatocarcinogen 4-dimethylaminoazobenzene and is not observed after an injection of the non-carcinogenic analogue 4-diethylaminoazobenzene. It is noteworthy, that this chromatin alteration resulting from carcinogen treatment is temporary, since on the 11th day following such treatment the kidney antigen is no longer found.
对从完整大鼠的肝脏和肾脏染色质以及Zajdela肝癌细胞中分离出的非组蛋白（NHP）-DNA复合物的抗原特性进行的比较研究表明，在后者中存在一种肾脏染色质特有的抗原成分，但在完整大鼠的肝脏染色质中从未出现过。在单次注射肝癌致癌物4-二甲基氨基偶氮苯后的4-7天，在大鼠肝脏中发现了类似的抗原成分，而注射非致癌类似物4-二乙氨基偶氮苯后未观察到这种成分。值得注意的是，这种由致癌物处理导致的染色质改变是暂时的，因为在这种处理后的第11天，肾脏抗原不再被发现。
