Reeback J, Silman A
J R Soc Med. 1984 Dec;77(12):1002-5. doi: 10.1177/014107688407701203.
The prognostic value of clinical and laboratory measures in 72 patients with rheumatoid arthritis (RA), seen initially within 18 months of disease onset, in predicting function outcome after a further two years was assessed. Limitation of wrist extension was associated with a slow disease onset, a high articular index and a high latex titre. A reduction in global functional capacity, as measured by the Stanford Health Assessment Questionnaire, was associated with a high initial articular index and a high latex titre. Neither outcome was associated with the initial level of acute phase reactants nor with patient or physician's initial assessment of disease activity. It is concluded, first, that factors predicting early disability outcome in RA are not identical to those associated with continuing disease activity; and secondly, that patients' and physicians' judgment of disease activity at diagnosis do not carry any prognostic value for functional outcome two years later.
对72例类风湿关节炎（RA）患者进行了评估，这些患者在疾病发作后的18个月内首次就诊，研究临床和实验室指标对再过两年后功能结局的预测价值。腕关节伸展受限与疾病起病缓慢、高关节指数和高乳胶滴度相关。通过斯坦福健康评估问卷测量的整体功能能力下降与高初始关节指数和高乳胶滴度相关。两种结局均与急性期反应物的初始水平无关，也与患者或医生对疾病活动的初始评估无关。得出的结论是，首先，预测RA早期残疾结局的因素与持续疾病活动相关的因素不同；其次，患者和医生在诊断时对疾病活动的判断对两年后的功能结局没有任何预后价值。
