Karat A B, Rao P S
Lepr India. 1978 Jan;50(1):18-25.
321 adult male lepromatous leprosy patients were studied for relationship between haematological findings, severity of disease and duration of treatment. Significant changes were noticed in relation in haemoglobin concentration, serum vitamin B12 and serum folate levels, serum albumin and globulin. No significant changes were observed in serum iron levels in relation to disease and treatment status. With rising bacterial load, there was a trend towards lower haemoglobin concentration, higher vitamin B12 level and lowered serum folate levels. Serum albumin showed a significant decline, while serum globulin showed a significant rise. The findings are discussed in relation to replacement of bone marrow by lepromatous tissue as well as possible interference in the metabolism of haematinics by M. leprae. The exact mechanism of neurlogical deficit in leprosy in relation to deficiency of vitamin B12 and folic acid need to be further elucidated.
对321名成年男性瘤型麻风患者进行了血液学检查结果、疾病严重程度和治疗持续时间之间关系的研究。观察到血红蛋白浓度、血清维生素B12和血清叶酸水平、血清白蛋白和球蛋白方面有显著变化。血清铁水平在疾病和治疗状态方面未观察到显著变化。随着细菌载量的增加，血红蛋白浓度有降低趋势，维生素B12水平升高，血清叶酸水平降低。血清白蛋白显著下降，而血清球蛋白显著上升。结合瘤型组织对骨髓的替代以及麻风杆菌对造血物质代谢可能的干扰对这些发现进行了讨论。麻风病中与维生素B12和叶酸缺乏相关的神经功能缺损的确切机制需要进一步阐明。
