Balonov M I, Pomerantseva M D, Ramaĭia L K
Radiobiologiia. 1984 Nov-Dec;24(6):753-7.
The frequency of dominant lethal mutations (DLM) in differentiating spermatogenic cells and of reciprocal translocations (RT) in stem spermatogonia, as well as the loss of testis mass were determined after the administration of 3.3 MBq/D-glucose-6(3)H to mice. The absorbed dose in germ cells amounted to 0.95 +/- 0.06 Gy with 17% of the dose being attributed to radiation from bound tritium. The levels of the genetic effects of DLM and RT and the dependence of the DLM frequency upon the stage of the irradiated cell were nearly the same as those observed in the experiment with tritium oxide. The loss of testis mass to 54% of the control, 30 days after exposure, resembled that produced by THO. The value of the reaction determined by all three tests was in accordance with the value of the absorbed dose with regard to the known doubled effectiveness of low-energy beta-radiation and did not need the hypothesis of the heterogeneity of the dose distribution and the influence of tritium transmutation.
给小鼠注射3.3 MBq的D-葡萄糖-6(3)H后，测定了分化生精细胞中显性致死突变（DLM）的频率、精原干细胞中相互易位（RT）的频率以及睾丸质量的损失。生殖细胞的吸收剂量为0.95±0.06 Gy，其中17%的剂量归因于结合氚的辐射。DLM和RT的遗传效应水平以及DLM频率对受照射细胞阶段的依赖性与氧化氚实验中观察到的情况几乎相同。照射后30天，睾丸质量损失至对照的54%，与THO产生的情况相似。就低能β辐射已知的双倍有效性而言，由所有三项测试确定的反应值与吸收剂量值一致，不需要剂量分布不均匀性和氚嬗变影响的假设。
