Kaneti J, Winikoff Y, Zimlichman S, Shainkin-Kestenbaum R
Urol Res. 1984;12(5):239-41. doi: 10.1007/BF00256147.
Serum amyloid A (SAA) and acid phosphatase (AcP) levels were determined in serial serum samples of 35 patients in different stages of dissemination and correlated with activity of carcinoma of the prostate. Up to 500-fold increases in SAA level were detected during active periods of cancer with a decrease towards the normal range in remission, in comparison with a 10-fold increase of AcP. The correlation between these two parameters was highly significant (P less than 0.001), but while SAA shows 100% sensitivity during the active stage, AcP shows only 85% sensitivity. It is suggested that although SAA is not a specific marker for any particular illness, due to its characteristic pattern of change in malignant diseases and its high sensitivity, it represents a useful biochemical parameter for the assessment of the activity of the disease to monitor response to therapy during follow-up.
测定了35例处于不同播散阶段患者的系列血清样本中的血清淀粉样蛋白A（SAA）和酸性磷酸酶（AcP）水平，并将其与前列腺癌的活性相关联。与AcP升高10倍相比，在癌症活跃期检测到SAA水平升高达500倍，缓解期则降至正常范围。这两个参数之间的相关性非常显著（P小于0.001），但在活跃期SAA的敏感性为100%，而AcP仅为85%。研究表明，虽然SAA不是任何特定疾病的特异性标志物，但由于其在恶性疾病中的特征性变化模式及其高敏感性，它是评估疾病活性、监测随访期间治疗反应的有用生化参数。
