Shainkin-Kestenbaum R, Zimlichman S, Winikoff Y, Pras M, Chaimovitz C, Sarov I
Clin Exp Immunol. 1982 Dec;50(3):503-6.
Serum amyloid A (SAA) levels were determined in the serial serum samples of eight rubella, 10 measles and seven subacute sclerosing panencephalitis (SSPE) patients. An early rise in SAA levels was detected in the acute phase in rubella and measles, followed by a prompt decrease in the convalescent phase. In a number of measles and rubella patients from whom early serum samples were available, the rise of SAA levels could be demonstrated before specific viral antibodies could be detected by complement fixation (CF) (measles) and haemagglutination inhibition (HI) (rubella). In only one rubella and one measles patient was no rise of SAA level detected. In SSPE only a moderate increase in SAA levels was noted except in one patient during a temporary deterioration, at which time the SAA level was very high; it returned to close to normal shortly thereafter. The possibility that SAA levels might be of value in monitoring the severity of infections, the recovery process and effects of anti-viral agents is discussed.
测定了8例风疹患者、10例麻疹患者和7例亚急性硬化性全脑炎（SSPE）患者的系列血清样本中的血清淀粉样蛋白A（SAA）水平。在风疹和麻疹的急性期检测到SAA水平早期升高，随后在恢复期迅速下降。在一些可获得早期血清样本的麻疹和风疹患者中，在通过补体结合试验（CF）（用于麻疹）和血凝抑制试验（HI）（用于风疹）检测到特异性病毒抗体之前，就可以证明SAA水平升高。仅1例风疹患者和1例麻疹患者未检测到SAA水平升高。在SSPE患者中，除1例患者在病情暂时恶化期间SAA水平非常高外，仅注意到SAA水平有中度升高；此后不久其恢复至接近正常水平。本文讨论了SAA水平在监测感染严重程度、恢复过程及抗病毒药物疗效方面可能具有价值的可能性。
