On-line pharmacokinetics of chloramphenicol in rat cortex by in vivo electrochemical detection.

In vivo electrochemical detection of chloramphenicol in rat cortex was investigated with microelectrodes after intravenous injection of chloramphenicol succinate (170 mg X kg-1). A classical pharmacokinetic study with high-performance liquid chromatography (HPLC) determination of chloramphenicol was performed. The two methods gave the same result when chloramphenicol and chloramphenicol succinate were added for the HPLC assay and compared with the voltametric assay. Clinical applications of this new method are suggested.