Degawa M, Kojima M, Hashimoto Y
Gan. 1984 Nov;75(11):966-75.
Male Donryu rats and B6C3F1 mice were treated with dietary 3-methoxy-4-aminoazobenzene (3-MeO-AAB) (0.06% or 0.09%), and subcellular fractions of the liver were examined for ability to mutagenically activate 3-MeO-AAB and 2 amino acid pyrolysate components using Salmonella typhimurium TA 98 as a tester strain. The treatment resulted in striking induction of enzyme(s) for the mutagenic activation of these aromatic amines in rats, but the effect was smaller in mice. The enzyme(s) involved in the reaction was characterized as an isotype of microsomal cytochrome P-448.
雄性Donryu大鼠和B6C3F1小鼠用含0.06%或0.09%的膳食3-甲氧基-4-氨基偶氮苯（3-MeO-AAB）进行处理，以鼠伤寒沙门氏菌TA 98作为测试菌株，检测肝脏亚细胞组分对3-MeO-AAB和2种氨基酸热解产物成分进行诱变活化的能力。该处理导致大鼠中用于这些芳香胺诱变活化的酶显著诱导，但在小鼠中的作用较小。参与该反应的酶被鉴定为微粒体细胞色素P-448的一种同工型。
