Abbasi A A, Chemplavil J K, Farah S, Muller B F, Arnstein A R
Ann Intern Med. 1979 Mar;90(3):324-8. doi: 10.7326/0003-4819-90-3-324.
We ascertained the incidence of hypercalcemia in 79 consecutive patients with active pulmonary tuberculosis and a control group of 79 patients with chronic obstructive pulmonary disease. Twenty-two patients developed hypercalcemia (serum calcium greater than 10.5 mg/dl) within 4 to 16 weeks after initiation of chemotherapy for tuberculosis. The duration of hypercalcemia ranged from 1 to 7 months, and remission occurred spontaneously in all patients. The mean daily vitamin D supplement was greater in hypercalcemic patients than in the normocalcemic group. There was a positive correlation between daily vitamin D supplement and degree and duration of hypercalcemia. Mean serum calcium in patients with tuberculosis was higher than in patients with chronic obstructive pulmonary disease supplemented with the same dose of vitamin D. Hypercalcemia appears to be related to the activity of pulmonary tuberculosis and the intake of vitamin D; the exact mechanism, however, remains unknown.
我们确定了79例活动性肺结核患者以及79例慢性阻塞性肺疾病患者作为对照组的高钙血症发生率。22例患者在开始抗结核化疗后的4至16周内出现高钙血症（血清钙大于10.5mg/dl）。高钙血症持续时间为1至7个月，所有患者均自发缓解。高钙血症患者每日维生素D补充量高于血钙正常组。每日维生素D补充量与高钙血症的程度和持续时间呈正相关。补充相同剂量维生素D的情况下，肺结核患者的平均血清钙高于慢性阻塞性肺疾病患者。高钙血症似乎与肺结核的活动及维生素D的摄入有关；然而，确切机制尚不清楚。
