Podleski W K, Panaszek B A, Schmidt J L, Burns R B
Agents Actions. 1984 Oct;15(3-4):177-81. doi: 10.1007/BF01972346.
Electron microscopic studies provided evidence that a patient with cow's milk allergy, manifested as bronchial asthma, has prominent eosinophil granule discharge, attributable to the release of cytotoxic major basic protein (MBP). This finding illustrates a critical role of eosinophil MBP in anaphylactic injury induced by food allergen. Patient white blood cells pretreated with Ketotifen revealed intact ultrastructure of eosinophils granules and cytoplasm. Inhibition of eosinophils degranulation by Ketotifen demonstrates a new pharmacologic mode of action of this anti-allergic, anti-anaphylactic agent.
电子显微镜研究提供了证据，表明一名表现为支气管哮喘的牛奶过敏患者有明显的嗜酸性粒细胞颗粒释放，这归因于细胞毒性主要碱性蛋白（MBP）的释放。这一发现说明了嗜酸性粒细胞MBP在食物过敏原诱导的过敏损伤中的关键作用。用酮替芬预处理的患者白细胞显示嗜酸性粒细胞颗粒和细胞质的超微结构完整。酮替芬对嗜酸性粒细胞脱颗粒的抑制作用证明了这种抗过敏、抗过敏剂的一种新的药理作用模式。
