Banerjee U, Izquierdo J A
Acta Physiol Lat Am. 1982;32(4):277-85.
The antistress and antifatigue properties of a Chinese ginseng preparation were tested on Swiss albino mice, exposed to various experimental models of stress, and were compared with those of piracetam. Both ginseng and piracetam were administered chronically in drinking water for 16-18 days as well as acutely, by injection, 30-60 min prior to the experiments. Reactivity of the mice, loss in body weight, amount of faeces, length of endurance and incidence of mortality were graded and measured. Both piracetam and ginseng treatment provided good protection against electroshock stress when compared to the untreated mice; fighting scores, incidence of tonic convulsion and mortality were significantly less in the treated groups. In the heat stress experiments, both piracetam and ginseng provided significant protection to the treated mice against exposure to heat. In the fatigue stress of forced swim test, ginseng treatment provided effective adaptation to fatigue and increased endurance in both male and female mice; piracetam showed some antifatigue effects on the male mice only. In the locomotor activity tests, ginseng did not depress motility, while piracetam did so in the later part of the tests. These results are discussed in the light of the antistress properties of the drugs as reported in the literature.
在暴露于各种应激实验模型的瑞士白化小鼠身上测试了一种人参制剂的抗应激和抗疲劳特性，并与吡拉西坦的特性进行了比较。人参和吡拉西坦均通过饮用水长期给药16 - 18天，并在实验前30 - 60分钟通过注射进行急性给药。对小鼠的反应性、体重减轻、粪便量、耐力时长和死亡率进行分级和测量。与未治疗的小鼠相比，吡拉西坦和人参治疗均能有效抵御电休克应激；治疗组的搏斗评分、强直性惊厥发生率和死亡率均显著降低。在热应激实验中，吡拉西坦和人参均能为受试小鼠提供显著的热暴露防护。在强迫游泳试验的疲劳应激中，人参治疗能使雄性和雌性小鼠有效适应疲劳并提高耐力；吡拉西坦仅对雄性小鼠显示出一定的抗疲劳作用。在运动活动测试中，人参不会抑制运动能力，而吡拉西坦在测试后期会抑制运动能力。根据文献报道的药物抗应激特性对这些结果进行了讨论。
