Lücker P W, Beubler E, Kukovetz W R, Ritter W
Dermatologica. 1984;169 Suppl 1:51-5. doi: 10.1159/000249639.
The retention time and the extent of penetration in human skin of [14C] labelled bifonazole in comparison to [14C] labelled clotrimazole were investigated in 8 healthy volunteers. In the course of the investigation the backs of the volunteers were treated half with bifonazole, half with clotrimazole which remained on the skin for 24 h. From 24 to 168 h after the administration the skin was stripped with the tear-off strip technique. Three dermal layers of different depth were examined. The results of the examinations revealed, that the quantity of bifonazole that penetrated into the skin was more than twice as high as the quantity of clotrimazole. However, the half-lives and the mean retention times of bifonazole and clotrimazole were nearly similar to each other.
在8名健康志愿者身上，对[14C]标记的联苯苄唑与[14C]标记的克霉唑相比，在人皮肤中的保留时间和渗透程度进行了研究。在研究过程中，志愿者的背部一半用联苯苄唑治疗，一半用克霉唑治疗，药物在皮肤上保留24小时。给药后24至168小时，采用撕脱条技术对皮肤进行剥离。检查了三个不同深度的真皮层。检查结果显示，渗透到皮肤中的联苯苄唑量是克霉唑量的两倍多。然而，联苯苄唑和克霉唑的半衰期和平均保留时间彼此几乎相似。
