Ikeda I, Nakashima-Yoshida K, Sugano M
J Nutr Sci Vitaminol (Tokyo). 1985 Jun;31(3):375-84. doi: 10.3177/jnsv.31.375.
The possibility that cycloartenol magnifies the hypocholesterolemic effect of beta-sitosterol was studied in two strains of rats fed on cholesterol-enriched (0.5%) diets. Cycloartenol was added to diets containing 1.0% or 0.5% beta-sitosterol at the 0.05% level and to diet free of plant sterol at the 0.5% level. In one experiment, diets included sodium cholate (0.125%). Due to the potent hypocholesterolemic efficacy of beta-sitosterol under the present dietary regimens, no clear additional effect (so-called synergistic effect) of cycloartenol was observed. However, in the experiment using Wistar rats, the decrease in serum apo A-I due to feeding cholesterol was ameliorated more effectively in combination with beta-sitosterol than with beta-sitosterol alone. The hepatic deposition of cholesterol was mitigated by dietary beta-sitosterol, and further, although slightly, by a combination of beta-sitosterol and cycloartenol, except in the experiment with diets containing sodium cholate. Fecal excretion of neutral and acidic steroids was not meaningly magnified by cycloartenol. Cycloartenol itself was not as effective as beta-sitosterol in mitigating lipid disorders due to dietary cholesterol. The rate of appearance of cholesterol in the thoracic duct lymph was not interfered with further by a combination of beta-sitosterol and cycloartenol compared to beta-sitosterol alone. This trimethylsterol was absorbed at a rate approximately 4-fold higher than that of beta-sitosterol, though much lower compared to cholesterol. These results suggest a preference for cycloartenol in cholesterol dynamics. However, cycloartenol seems unlikely to influence cholesterol absorption in the small intestine.
在两组喂食富含胆固醇（0.5%）饮食的大鼠中，研究了环阿屯醇是否会增强β-谷甾醇的降胆固醇作用。环阿屯醇以0.05%的水平添加到含有1.0%或0.5%β-谷甾醇的饮食中，并以0.5%的水平添加到不含植物甾醇的饮食中。在一项实验中，饮食中包含胆酸钠（0.125%）。由于在当前饮食方案下β-谷甾醇具有强大的降胆固醇功效，未观察到环阿屯醇有明显的额外作用（即所谓的协同作用）。然而，在使用Wistar大鼠的实验中，与单独使用β-谷甾醇相比，联合使用β-谷甾醇能更有效地改善因喂食胆固醇导致的血清载脂蛋白A-I降低。饮食中的β-谷甾醇可减轻肝脏中胆固醇的沉积，此外，β-谷甾醇与环阿屯醇联合使用（含胆酸钠的饮食实验除外）虽作用轻微，但也能进一步减轻肝脏中胆固醇的沉积。环阿屯醇不会显著增加中性和酸性类固醇的粪便排泄量。环阿屯醇本身在减轻因饮食胆固醇导致的脂质紊乱方面不如β-谷甾醇有效。与单独使用β-谷甾醇相比，β-谷甾醇与环阿屯醇联合使用不会进一步干扰胸导管淋巴中胆固醇的出现率。这种三甲基甾醇的吸收率比β-谷甾醇高约4倍，不过与胆固醇相比要低得多。这些结果表明在胆固醇动态变化中环阿屯醇具有一定优势。然而，环阿屯醇似乎不太可能影响小肠中的胆固醇吸收。
