Tokola R A, Neuvonen P J
Br J Clin Pharmacol. 1984 Dec;18(6):867-71. doi: 10.1111/j.1365-2125.1984.tb02557.x.
The absorption of effervescent paracetamol (1000 mg) was investigated in nine female patients during a migraine attack and in the same patients when headache free. Migraine attack decreased (P less than 0.05) the areas under the serum paracetamol concentration-time curves (AUC) of 0-2 h, 0-4 h and 0-6 h and the peak serum concentration. The severity of nausea correlated significantly with the decrease in the AUC values. Our results support findings of delayed gastric emptying in migraine attacks. Both a delay and an impairment of drug absorption may follow.
在9名女性患者偏头痛发作期间及无头痛时，对泡腾对乙酰氨基酚（1000毫克）的吸收情况进行了研究。偏头痛发作使0 - 2小时、0 - 4小时和0 - 6小时血清对乙酰氨基酚浓度 - 时间曲线下面积（AUC）以及血清峰值浓度降低（P < 0.05）。恶心的严重程度与AUC值的降低显著相关。我们的结果支持偏头痛发作时胃排空延迟的研究发现。药物吸收可能随之出现延迟和受损。
