Findlay J W, Butz R F, Sailstad J M, Warren J T, Welch R M
Br J Clin Pharmacol. 1984 Dec;18(6):901-6. doi: 10.1111/j.1365-2125.1984.tb02562.x.
Plasma and milk concentrations of pseudoephedrine and triprolidine were determined (by radioimmunoassay) in three lactating mothers over 12-48 h after ingestion of a combination medication containing 60 mg of pseudoephedrine hydrochloride and 2.5 mg of triprolidine hydrochloride monohydrate. Pseudoephedrine concentrations in milk were consistently higher than those in plasma. The total amount of drug in milk, as judged by areas under the respective curves (AUC), was two to three times greater than in plasma. Triprolidine concentrations in milk and plasma were more variable between subjects than those of pseudoephedrine. AUC values for milk and plasma were similar for one subject, while the plasma value exceeded that for milk in another woman. The fraction of the dose excreted in milk was estimated to be 0.4-0.7% for pseudoephedrine and 0.06-0.2% for triprolidine.
在三名哺乳期母亲摄入含有60毫克盐酸伪麻黄碱和2.5毫克一水合盐酸曲普利啶的复方药物后的12至48小时内，测定了（通过放射免疫分析法）她们血浆和乳汁中伪麻黄碱和曲普利啶的浓度。乳汁中的伪麻黄碱浓度始终高于血浆中的浓度。根据各自曲线下面积（AUC）判断，乳汁中的药物总量比血浆中的高两到三倍。与伪麻黄碱相比，不同受试者之间乳汁和血浆中的曲普利啶浓度变化更大。一名受试者的乳汁和血浆的AUC值相似，而另一名女性的血浆值超过了乳汁值。估计伪麻黄碱经乳汁排泄的剂量分数为0.4 - 0.7%，曲普利啶为0.06 - 0.2%。
