克林霉素进入人乳的情况。
Clindamycin passage into human milk.
作者信息
Stéen B, Rane A
出版信息
Br J Clin Pharmacol. 1982 May;13(5):661-4. doi: 10.1111/j.1365-2125.1982.tb01433.x.
Abstract
1 The clindamycin bioactivity was measured during the dosage interval in the plasma of women with puerperal infections and in their breast milk. 2 There was a marked interindividual variation in the peak levels. The clindamycin bioactivity in the milk ranged from 1/10 to several times the corresponding bioactivity in the plasma that was collected at the same time. 3 The concentration of clindamycin in the milk (bioactivity) at the end of the dosage interval correlated with the area under the plasma concentration v time curve. 4 Clindamycin is thus transferred into human breast milk. Although the actual amounts secreted are small, the wellknown side effects and the lack of knowledge about the disposition and effects of clindamycin in newborn infants are strong arguments against nursing during treatment with this drug.
摘要
- 在产褥期感染妇女的血浆及其母乳中，于给药间隔期间测定了克林霉素的生物活性。2. 峰值水平存在显著的个体间差异。乳汁中克林霉素的生物活性为同时采集的血浆中相应生物活性的1/10至数倍。3. 给药间隔结束时乳汁中克林霉素的浓度（生物活性）与血浆浓度-时间曲线下面积相关。4. 因此，克林霉素可转移至人母乳中。尽管实际分泌量很少，但众所周知的副作用以及对克林霉素在新生儿体内处置和作用的了解不足，是反对在使用该药物治疗期间进行母乳喂养的有力论据。
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本文引用的文献
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