Kaslow R A, Sullivan-Bolyai J Z, Hafkin B, Schonberger L B, Kraus L, Moore M J, Yunis E, Williams R M
Neurology. 1984 Feb;34(2):240-2. doi: 10.1212/wnl.34.2.240.
We compared Guillain-Barré syndrome (GBS) cases reported from cities in the United States in 1976-1977 with spouse or associate controls to detect possible HLA associations. HLA-A11 was somewhat less common among 92 cases than among 100 controls (p = 0.04). The 38 patients and 42 controls vaccinated against A/NJ/76 differed slightly in overall distribution of B locus antigens (p = 0.06), but the individual HLA-B antigen associations were more easily explained by chance. The 54 unvaccinated cases showed no apparent relation to HLA type. These findings should encourage further immunogenetic study of etiologically related GBS cases.
我们将1976 - 1977年美国各城市报告的吉兰 - 巴雷综合征（GBS）病例与配偶或相关对照进行比较，以检测可能的HLA关联。在92例病例中，HLA - A11的出现频率略低于100例对照（p = 0.04）。38例接种A/NJ/76疫苗的患者和42例对照在B位点抗原的总体分布上略有差异（p = 0.06），但各个HLA - B抗原关联更可能是偶然因素导致。54例未接种疫苗的病例与HLA类型无明显关联。这些发现应鼓励对病因相关的GBS病例进行进一步的免疫遗传学研究。
