前列腺素E1输注对雷诺综合征的血液流变学影响。
Haemorrheological effects of prostaglandin E1 infusion in Raynaud's syndrome.
作者信息
Lucas G S, Simms M H, Caldwell N M, Alexander S J, Stuart J
出版信息
J Clin Pathol. 1984 Aug;37(8):870-3. doi: 10.1136/jcp.37.8.870.
Abstract
Eighteen patients with severe Raynaud's syndrome had impaired deformability of erythrocytes, as measured by filtration through 5 micron diameter pores, compared with 19 healthy controls. The patients were given prostaglandin E1 (PGE1) or placebo by intravenous infusion for 72 h to assess the haemorrheological action of PGE1. Contrary to a previous report, PGE1 did not improve erythrocyte filterability. Infusion of PGE1 did, however, evoke an acute phase response with hyperproteinaemia and a leucocytosis and is a potentially important mediator of this stress response in patients with vascular disease.
摘要
与19名健康对照者相比，18名重度雷诺综合征患者的红细胞变形能力受损，这是通过红细胞经直径5微米的小孔滤过进行测量的。这些患者通过静脉输注给予前列腺素E1（PGE1）或安慰剂，持续72小时，以评估PGE1的血液流变学作用。与之前的一份报告相反，PGE1并未改善红细胞滤过率。然而，输注PGE1确实引发了急性期反应，伴有高蛋白血症和白细胞增多，并且是血管疾病患者这种应激反应的潜在重要介质。
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本文引用的文献
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BLOOD VISCOSITY AND RAYNAUD'S DISEASE.血液粘度与雷诺氏病
Lancet. 1965 May 22;1(7395):1086-8. doi: 10.1016/s0140-6736(65)92673-5.
2
Treatment of vasospastic disease with prostaglandin E1.用前列腺素E1治疗血管痉挛性疾病。
Br Med J. 1980 Oct 18;281(6247):1031-4. doi: 10.1136/bmj.281.6247.1031.
3
Haematological stress syndrome in atherosclerosis.动脉粥样硬化中的血液学应激综合征
J Clin Pathol. 1981 May;34(5):464-7. doi: 10.1136/jcp.34.5.464.
4
Serial study of C-reactive protein during infection in leukaemia.白血病感染期间C反应蛋白的系列研究
J Clin Pathol. 1981 Mar;34(3):263-6. doi: 10.1136/jcp.34.3.263.
5
Characterization of a leukocyte-derived endogenous mediator responsible for increased plasma fibrinogen.一种负责血浆纤维蛋白原增加的白细胞源性内源性介质的特性研究。
Ann N Y Acad Sci. 1982;389:338-53. doi: 10.1111/j.1749-6632.1982.tb22148.x.
6
Leukocytic pyrogen: a major mediator of the acute phase reaction.白细胞热原：急性期反应的主要介质。
Ann N Y Acad Sci. 1982;389:323-37. doi: 10.1111/j.1749-6632.1982.tb22147.x.
7
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