Lucas G S, Simms M H, Caldwell N M, Alexander S J, Stuart J
J Clin Pathol. 1984 Aug;37(8):870-3. doi: 10.1136/jcp.37.8.870.
Eighteen patients with severe Raynaud's syndrome had impaired deformability of erythrocytes, as measured by filtration through 5 micron diameter pores, compared with 19 healthy controls. The patients were given prostaglandin E1 (PGE1) or placebo by intravenous infusion for 72 h to assess the haemorrheological action of PGE1. Contrary to a previous report, PGE1 did not improve erythrocyte filterability. Infusion of PGE1 did, however, evoke an acute phase response with hyperproteinaemia and a leucocytosis and is a potentially important mediator of this stress response in patients with vascular disease.
与19名健康对照者相比，18名重度雷诺综合征患者的红细胞变形能力受损，这是通过红细胞经直径5微米的小孔滤过进行测量的。这些患者通过静脉输注给予前列腺素E1（PGE1）或安慰剂，持续72小时，以评估PGE1的血液流变学作用。与之前的一份报告相反，PGE1并未改善红细胞滤过率。然而，输注PGE1确实引发了急性期反应，伴有高蛋白血症和白细胞增多，并且是血管疾病患者这种应激反应的潜在重要介质。
