Blunt R J, George A J, Hurlow R A, Strachan C J, Stuart J
Br J Haematol. 1980 Aug;45(4):651-8. doi: 10.1111/j.1365-2141.1980.tb07188.x.
Whole-blood viscosity (measured at 128, 23 and 0.2 s-(1) was significantly increased in 29 females with Raynaud's syndrome, 13 males with vibration-induced Raynaud's syndrome, and 18 males with calf claudication secondary to atherosclerosis, as compared with 50 healthy controls matched for sex, age and smoking habit. Viscosity was higher at low temperature (27 and 22 degrees C) in all three types of vascular disease and, despite symptoms of cold hypersensitivity, patients with Raynaud's syndrome did not show selective hypersensitivity at low temperature. Patients with vascular disease, irrespective of aetiology, also showed an increase in the acute-phase reactants haptoglobin, fibrinogen, and factor VIII antigen, together with reduced fibrinolytic activity and minor activation of platelets. These alterations in viscosity and haemostatic factors in vascular disease are probably related to the degree, rather than the aetiology, of endothelial damage and their cumulative effect may contribute to local stasis and thrombosis, particularly in cold extremities.
与50名在性别、年龄和吸烟习惯方面相匹配的健康对照者相比，29名雷诺综合征女性患者、13名振动性雷诺综合征男性患者以及18名继发于动脉粥样硬化的小腿间歇性跛行男性患者的全血黏度（在128、23和0.2 s⁻¹下测量）显著升高。在所有三种类型的血管疾病中，低温（27和22摄氏度）下的黏度更高，并且尽管有冷超敏症状，但雷诺综合征患者在低温下并未表现出选择性超敏反应。无论病因如何，血管疾病患者的急性期反应物触珠蛋白、纤维蛋白原和凝血因子VIII抗原也会增加，同时纤溶活性降低，血小板轻度活化。血管疾病中这些黏度和止血因子的改变可能与内皮损伤的程度而非病因有关，它们的累积效应可能导致局部血流淤滞和血栓形成，尤其是在四肢寒冷的情况下。
