Watt G C, Edwards C, Hart J T, Hart M, Walton P, Foy C J
Br Med J (Clin Res Ed). 1983 Feb 5;286(6363):432-6. doi: 10.1136/bmj.286.6363.432.
Eighteen patients with stable mild hypertension (mean blood pressure 144/93 mm Hg) restricted their sodium intake for eight weeks while taking part in a double blind randomised crossover trial of slow sodium and placebo tablets. Mean 24 hour urinary sodium excretion was 143 mmol(mEq) during the period on slow sodium and 87 mmol during the period on placebo. Five patients were unable to reduce their sodium intake below 120 mmol, but the others had a mean 24 hour urinary sodium excretion of 59 mmol during the period on placebo. There was no significant difference in blood pressure between the slow sodium and placebo treatment periods, although the study had a power of 99% to detect a difference of 5 mm Hg in mean arterial pressure between the two periods. Moderate dietary sodium restriction does not lower blood pressure in patients with this degree of hypertension.
18名患有稳定轻度高血压（平均血压144/93毫米汞柱）的患者在参与一项关于慢效钠片和安慰剂片的双盲随机交叉试验期间，限制钠摄入8周。服用慢效钠片期间，24小时尿钠排泄均值为143毫摩尔（毫当量），服用安慰剂期间为87毫摩尔。5名患者无法将钠摄入量降至120毫摩尔以下，但其他患者在服用安慰剂期间24小时尿钠排泄均值为59毫摩尔。慢效钠片治疗期和安慰剂治疗期之间血压无显著差异，尽管该研究有99%的检验效能来检测这两个时期平均动脉压5毫米汞柱的差异。适度的饮食钠限制不会降低这种程度高血压患者的血压。
